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Effects of corneal thickness on the intraocular penetration of travoprost 0.004%.

Tipo: Artículo
Código: PMID: 22562189
Autores: Martinez-de-la-Casa JM, Rayward O, Saenz-Frances F, Santos-Bueso E, Mendez-Hernandez C, Herrero-Vanrell R, Garcia-Feijoo J, Garcia-Sanchez J.
Títuto Revista: Eye (Lond).
Referencia:
Colaboradores: Instituto de Investigaciones Oftalmológicas Ramón Castroviejo - UCM (RD07-0062-0000)y Grupo de Diseño de Productos Biomateriales Oftálmicos (DEPBO) de la Facultad de Farmacia de la UCM (RD07-0062-2002).
Centro: G09-Madrid

Abstract

PURPOSE:

To determine whether the intraocular penetration of travoprost 0.004% is affected by central corneal thickness.

METHODS:

Sixty-four patients who were scheduled for cataract surgery without any other ophthalmologic pathology of significance were enrolled in this study. At 120 min before surgery, one drop of travoprost 0.004% was instilled in the eye to be operated on. At the start of surgery, a sample of aqueous humour was extracted to subsequently determine its AL-5848 concentration. These concentrations were compared among three groups of patients established according to central corneal thickness measurements obtained by ultrasound pachymetry.

RESULTS:

Mean AL-5848 concentrations were 3.27±2.03 ng/ml in Group I (CCT<511 microns), 3.27±2.44 ng/ml in Group II (CCT≥511 and ≤574 microns), and 2.73±2.15 ng/ml in Group III (CCT>574 microns), indicating no significant differences among the groups.

CONCLUSIONS:

We were unable to demonstrate the greater or lesser penetration of travoprost depending on corneal thickness, which could explain differences in patient responses to this drug.