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Short-term efficacy and safety of intravitreal ranibizumab for myopic choroidal neovascularization.

Tipo: Artículo
Autores: Silva RM, Ruiz-Moreno JM, Nascimento J, Carneiro A, Rosa P, Barbosaa A, Carvalheira F, Abreu JR, Cunha-Vaz JG.
Títuto Revista: Retina (Philadelphia, Pa.).
Referencia:
Centro: 02 - UCLM
Retina. 2008 Oct;28(8):1117-23.

Short-term efficacy and safety of intravitreal ranibizumab for myopic choroidal neovascularization.

Source

Department of Ophthalmology, University Hospital of Coimbra, Portugal. rufino.silva@oftalmologia.co.pt

Abstract

PURPOSE: To evaluate the safety and efficacy of intravitreal ranibizumab in the treatment of choroidal neovascularization (CNV) secondary to pathologic myopia (PM).

METHODS: Retrospective, multicenter, consecutive, nonrandomized, interventional case series.

PARTICIPANTS: Twenty-six eyes of 26 patients with CNV secondary to pathologic myopia; 11 eyes with previous photodynamic therapy; and 15 eyes with no previous treatment. Follow-up: 3 or more months. Best-corrected visual acuity (BCVA), ocular coherence tomography, and the presence of metamorphopsia were assessed monthly.

RESULTS: At 1 month, 31% of the eyes had an improvement in visual acuity of 3 or more lines. Twenty-six eyes completed 3 months of follow-up, and nine eyes completed 6 months of follow-up. Visual acuity improved significantly from 20/100 at baseline to 20/80 at 1 month (P = 0.003) to 20/63 at 3 months (P < 0.001), and 20/50 at 6 months (P = 0.01). A significant reduction in ocular coherence tomography central thickness was observed at 1, 3, and 6 months. No cases of severe visual acuity loss occurred, and no systemic or ocular side effects were registered during the follow-up.

CONCLUSION: Short-term results of intravitreal ranibizumab for myopic CNV are encouraging. Further prospective long-term studies are necessary to evaluate safety and efficacy of intravitreal ranibizumab in the treatment of myopic CNV.

PMID: 18788102 [PubMed - indexed for MEDLINE]