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Vitreous levels of interleukine-8 and monocyte chemoattractant protein-1 in macular oedema with branch retinal vein occlusion.

Tipo: Artículo
Autores: Fonollosa A, Garcia-Arumi J, Santos E, Macia C, Fernandez P, Segura RM, Zapata MA, Rodriguez-Infante R, Boixadera A, Martinez-Castillo V.
Centro: 05 - HVhebrón
Eye (Lond). 2010 Jul;24(7):1284-90. Epub 2010 Jan 29.

Vitreous levels of interleukine-8 and monocyte chemoattractant protein-1 in macular oedema with branch retinal vein occlusion.

Source

Department of Ophthalmology, Hospital Valle Hebron de Barcelona, Barcelona, Spain. 36427afc@comb.es

Abstract

PURPOSE:

To investigate whether interleukine-8 (IL-8) and monocyte chemoattractant protein-1 (MCP-1) are related with macular oedema in patients with branch retinal vein occlusions (BRVOs).

DESIGN:

Retrospective case-control study.

PARTICIPANTS:

Nineteen patients who had macular oedema due to BRVO and nine patients with non-ischaemic ocular diseases (control group).

METHODS:

Macular oedema was examined by optical coherence tomography. Both venous blood and vitreous samples were obtained at the time of vitreoretinal surgery. IL-8 and MCP-1 levels in vitreous fluid and plasma were determined with enzyme-linked immunosorbent assay kits. Variables were compared with the Mann-Whitney U-test, Wilcoxon's signed-ranked test, and the chi2-test, when appropriate. To examine correlations, Spearman's rank-order correlation coefficients were calculated. Statistical significance was set at P<0.05.

RESULTS:

The vitreous fluid levels of IL-8 (median: 63.5 pg/ml) and MCP-1 (median: 1522.4 pg/ml) were significantly higher in the patients with BRVO than in the control group (median: 5.1 and 746.5 pg/ml respectively; P<0.001 and <0.001 respectively). Vitreous IL-8 and MCP-1 were significantly correlated in patients with BRVO (P=0.009).

CONCLUSIONS:

Both IL-8 and MCP-1 were elevated in the vitreous fluid of patients with BRVO and macular oedema. Both chemokines may contribute to the pathogenesis of macular oedema in patients with BRVO.

PMID: 20111061 [PubMed - indexed for MEDLINE]