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Hypotensive effect of profilin on rabbit intraocular pressure.

Tipo: Artículo
Autores: Morales M, Gómez-Cabrero A, Peral A, Gasull X, Pintor J.
Títuto Revista: European Journal of Pharmacology
Colaboradores: Grupo de Investigación de Neurofisiología RD07/0062/0006; Grupo de Investigación de Bioquímica RD07/0062/0004.
Centro: 04 - UB
Eur J Pharmacol. 2007 Jul 12;567(1-2):145-8. Epub 2007 Apr 22.

Hypotensive effect of profilin on rabbit intraocular pressure.


Laboratory of Neurophysiology, Department of Physiological Sciences I, Institute of Biomedical Investigations August Pi I Sunyer (IDIBAPS), School of Medicine, University of Barcelona, Casanova 143, E-08036 Barcelona, Spain.


Ocular hypertension is a negative process that occurs within the eye and is the main risk factor to develop glaucoma, a progressive loss of vision due to degeneration of retinal ganglion cells. The protein transduction technique allows a cargo to cross biological membranes. Using this technique we have previously shown that a membrane permeable version of profilin I (PTD4-profilin) increased aqueous humour outflow facility. Here we have investigated if a topical application of PTD4-profilin was able to modify intraocular pressure in rabbits. 10 microM PTD4-profilin (10 microL), reduced intraocular pressure by 20% compared to the control vehicle, this value being in the range of other commercial drugs, which produced intraocular pressure reductions between 18 and 35%. The mean-time effect for PTD4-profilin was 6.8 h and was also in the same range as commercial products that provided values between 4.3 and 5.5 h. According to the results presented here we propose PTD4-profilin as a new approach for the treatment of ocular hypertension and PTD4 as a new strategy to facilitate the penetration of molecules into the eye.

PMID: 17499235 [PubMed - indexed for MEDLINE]