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Apoptosis in the trabecular meshwork of glaucomatous patients.

Tipo: Artículo
Autores: Baleriola J, García-Feijoo J, Martínez-de-la-Casa JM, Fernández-Cruz A, de la Rosa EJ, Fernández-Durango R.
Títuto Revista: Molecular Vision
Centro: 06 - UCM - IIORC
Mol Vis. 2008 Aug 18;14:1513-6.

Apoptosis in the trabecular meshwork of glaucomatous patients.


3D Lab (Development, Differentiation, & Degeneration), Department of Cellular and Molecular Physiopathology, Centro de Investigaciones Biológicas, CSIC, Madrid, Spain.


We established and validated an in toto method to perform TdT-mediated dUTP nick end labeling to study apoptosis in human trabecular meshwork tissue obtained during trabeculectomy in glaucoma patients. In specimens from patients with primary open-angle glaucoma and primary angle-closure glaucoma, we detected a tendency for more apoptotic cells to accumulate in patients with primary open-angle glaucoma. The utility of this method to study apoptosis in the trabecular meshwork is discussed, as well as its application as a tool in biologic samples.

PMID: 18728789 [PubMed - indexed for MEDLINE]

PMCID: PMC2518170

Free PMC Article

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